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Deep, qualified up coming-generation sequencing has unveiled that subclonal mutations (i.e., People existing in just a fraction of tumor cells) is usually detected for all driver genes and so are affiliated with rapid illness progression and lousy consequence.11–thirteen This is especially suitable for TP53

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The presence of driver alterations is related to rapid development. Even though a handful of alterations are enriched in CLL in comparison to MBL, each phases share the same driver composition. (

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